Propylene Glycol

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Versus

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Jun 11, 2011
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I just posted a review on Amazon. While it was about Systane, an eye lubricant, it's main ingredient is propylene glycol. I included some comments about propylene glycol in e-liquids. Thought I would post my comments here, also.

5.0 out of 5 stars Systane for Dry Eye Relief, April 4, 2012
By
Versus (Fleming County, Kentucky) - See all my reviews



This review is from: Systane Eye Drops, Lubricant, Long Lasting 0.5 fl oz (15 ml) (Health and Beauty)
Systane Ultra Lubricant Eye Drops, 2-count .33 fl oz (10 ml) BottleI am mostly writing this to present a balanced review profile. Systane..."works on two levels to help reduce the symptoms of dry eye, offering both long-lasting relief and an enhanced ENVIRONMENT for ocular surface repair". The emphasis on environment is mine. Note that Systane does not directly repair the eye surface, rather it provides a more lubricated eye environment by sustaining an adequate tear film on the eye. I have used Systane as recommended to me by my eye surgeon. In addition to what I have read about Systane, he emphasized to me that Systane's intended purpose is to improve moisture on the eye surface which would lead to increased eye comfort and help prevent damage caused by dry eye. "Most eye lubricants only add volume to the tear film, providing only short-term relief. "SYSTANE® works with your tears to prevent them from dissipating as quickly, offering long-lasting relief." The quotes are from the Systane professional web site. There is an excellent video on the professional site that explains how Systane is able to sustain a longer lasting adequate tear film on the eye. I am not affiliated with Alcon, the maker of Systane, but I am a health care practitioner.

At the time of writing this, there is only one other reviewer for this product. That reviewer stated that her vision worsened while using this product. I suppose that is possible if, for instance, she had some kind of allergy or sensitivity to an ingredient in the Systane. But that could be said of any medication. The main active ingredient is propylene glycol. Propylene glycol is a lubricant. It is also currently one of the two main ingredients used in e-liquids for electronic cigarettes (e-cigs). I recently read an article in which the author pointed to a very small study of e-cig users versus cigarette smokers that seemed to indicate that propylene glycol might be a mild irritant but it was also stated that the irritation was short lived and there was no indication of any long term effect. (By the way, that study also found that short term lung function was better in e-cigarette users versus cigarette smokers.) The Material Safety Data Sheet (MSDS) for propylene glycol lists it as a hygroscopic (attracts water). It also says that propylene glycol MAY be a mild respiratory irritant. The problem that I have when I read any suggestion of irritation with propylene glycol is that propylene glycol has long been used in respiratory inhalers for asthmatics. Huh? So, if propylene glycol is a respiratory irritant, albeit mild, why has it been used in inhalers for asthmatics for years? Must be very darn mild irritation. if any, don't you think? The Agency for Toxic Substances & Disease Registry (ATSDR) lists propylene glycol as GRAS, generally recognized as safe when used as an additive for foods and medications.

If the other reviewer is convinced that Systane actually caused problems for her eyes, then she should stop using it But my current opinion, unless proven otherwise, is that more than likely the vast majority of users are not going to have problems with it and that Systane will help them. The very minimal risk, if there truly is any, is far outweighed by the benefit. Alcon, the maker of Systane, is a respected name in eye care products along with Bausch and Lomb. The other reviewer stated that he/she read that the best eye drops use normal saline. Normal saline is just salt water at a concentration of 0.9%, which mimics the body's concentration of salt in body fluids. Normal saline has long been used to provide moisture to the eye and is in many eye products. Normal saline is used to rinse, moisten contact lenses for instance. However, it provides only brief improvement in moisture as compared to Systane which provides a sustained increase in the tear film. I repeat, normal saline is just water with a little salt. So, in effect the other reviewer is giving up a longer acting lubricant in favor of a very short acting lubricant, normal saline. Based on my current knowledge, it wouldn't be my choice by a long shot! Systane provides relief for my eye dryness, definitely better than using saline drops, and I will be continuing to use it.

I did not get my Systane from Amazon, I started with the sample I was provided by my eye surgeon, then when I needed more, I got it from my local pharmacy because I was already there for something else - convenience factor. However, I do plan to continue using it and will likely be buying it from Amazon in the future. I use Systane Ultra during the day. I decided to try the Systane gel or ointment for eye moisture protection at night, so I will be buying one of those on Amazon today. If I ever hear anything that makes me change my current opinion of Systane, I will try to remember to update here.
 

callmemario

Full Member
Sep 8, 2012
29
6
Montreal
Hello Versus,

I have been vaping for 3 weeks now and I love it but my body doesn't. For about two weeks, I was getting headaches after 8 or 10 drags. Tinitus in left ear some throat irritation and worst of all and persisting to this day under the eyes puffyness, like they feel congested. Took a look into my lower eye lid and found the membrane to be reddish and with a few small bubble like bumps.

I am REALLY sad and disapointed. I had cut down a lot on my smoking like 3 a day. I am waiting for some vegetable glycerine e juice only and hope it makes a difference or is it that it's the vapors itself irritating my eyes. In a ny event I am a little scared of persisting.
 

karlsudo

Full Member
Aug 12, 2012
18
3
ID
I am still investigating my proper ratio :). After a very satisfying first batch e-liq 75/25 pg/vg with double flavor, I tried 30/70 pg/vg standard flavor for my second batch. Relative to my first batch, flavor so muted, scratchy/dry throat, dry mouth, ulcers, coughing, all and all a total dang where goes my joyful vaping experience? I was prepared for a "slightly" muted flavor, a definitive more vapor. Not this! Thought since I so enjoy PG bas, and have no allergic reaction, certainly VG, generally said to be alternative for those allergic to PG, should be oh just fine. Obviously, should've read more about e-liq here on ecf rather than spending so much time admiring those shiny tubes :D.
 

Rickajho

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Apr 23, 2011
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"The Agency for Toxic Substances & Disease Registry (ATSDR) lists propylene glycol as GRAS, generally recognized as safe when used as an additive for foods and medications."

Peanut butter is generally recognized as safe. Unless you have an anaphylactic allergic reaction to it. There is no reason to discredit the very real allergic reactions some people do have to PG. For those with short historical memory spans I suggest you revisit the history of just how safe DDT was. If you read the MDSS's at Dow Chemical's web site you will leave with the impression that inhaling PG is actually better than air, despite their own notation that a percentage of the participants in trials did experience respiratory irritation from exposure.
 
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callmemario

Full Member
Sep 8, 2012
29
6
Montreal
OMG...all your comments are somewhat NOT very reassuring.
I would really be interested to have an on line statistical survey In 3 seperate categories: PG, VG and 50/50. of all side effects experience by first time e-vapers and more experienced like 6 months plus. ie: Eye irritation/congestion/redness, throat irritation, ear/nose problems, headaches, neural reactions, dizziness. skin reactions. etc... All of these NOT to be mixed up with withdrawal symptoms from cigarettes.

Anybody else had EYE reactions with any of the e-liquids?

Mario
 

callmemario

Full Member
Sep 8, 2012
29
6
Montreal
I thought I would let everyone know that I am doing much better tonight with vaping 100% VG juices!!...AND I've actually bought some Virginia tobaco blend/ 100%VG with 5mg of NIC which I had never tried since the 3 weeks I began vaping! I love it! :)

OMG...all your comments are somewhat NOT very reassuring.
I would really be interested to have an on line statistical survey In 3 seperate categories: PG, VG and 50/50. of all side effects experience by first time e-vapers and more experienced like 6 months plus. ie: Eye irritation/congestion/redness, throat irritation, ear/nose problems, headaches, neural reactions, dizziness. skin reactions. etc... All of these NOT to be mixed up with withdrawal symptoms from cigarettes.

Anybody else had EYE reactions with any of the e-liquids?

Mario
 

Rickajho

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Apr 23, 2011
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I thought I would let everyone know that I am doing much better tonight with vaping 100% VG juices!!...AND I've actually bought some Virginia tobaco blend/ 100%VG with 5mg of NIC which I had never tried since the 3 weeks I began vaping! I love it! :)

Congrats! I hope you do find this to be a working solution. What you listed in your previous post are all classic allergic reactions. Not just to PG, that's pretty much my laundry list of symptoms of an allergic reaction to any allergen.

Again, this is not a problem for the large majority of vapers. But the potential is there and why I always suggest that anyone new to vaping stick with small sample sizes, in both high PG and high VG, to check for any exposure problems to either type of base. There is nothing worse than a huge initial $$$ outlay on a pile of liquids, only to discover you can't vape any of it. In my case the difference in reaction to a high PG liquid versus a high VG liquid was far from subtle and only took four days to reach a peak allergic reaction. PG liquid? Nausea, vomiting, difficulty breathing and intense itching on hands and forearms. VG liquid? None of that. At all.

When I started I had no idea I could have an allergic reaction to any of this. But because I stuck to samples sizes on that first order I minimized my losses to a 5 ml bottle of PG liquid and 10 pre-filled carts. And at least the carts could be rinsed out and reused.
 

j4mmin42

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Jul 1, 2009
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High-PG liquids sometimes cause me to have a bit of asthma if I chain vape...but I can't stand the tast of pure pg anymore anyway-it just tastes chemmy to me at high concentrations. If you find a liquid that is PG and you have adverse reactions to high-PG liquids, you can do what I do and get some pharma-grade VG, order the PG eliquid you love with extra flavoring added AND a higher nic concentation, and mix the VG with it per the DIY boards' mixing ratio tutorials (or figure it out yourself-any middle-schooler can do the math here).

On another note, the is my 300th post! WOO

Fireworks.gif
 

callmemario

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Sep 8, 2012
29
6
Montreal
Thank you Rickajho! Yes, I think people who are more sensitive to allergies of all kinds might be more susceptible to react to PG/VG vapes as we most probably had allergic like reactions to the analog cigarette when we all started out smoking. But the analog cigarette NEVER EVER tasted good at the beginning, at least not for me. Without that nicotine, I don't think any of us would have persisted (unfortunately).
About sample size, you are quite right, I did not go on a splurge myself and bought 5ml bottles, but some vendors will not sell to you unless you buy a minimum order of let's say, $20.00...so you end up still buying a little more than what you had previously planned. But it's all for a good cause. As you well know when we are stating off in one thing, we don't yet know "all the tricks of the trade" ;-) This is where experience comes in, right? ;-)
As for allergic reactions, I've had nausea, upset stomach...but no vomiting, thank God! Poor you, that did not sound like fun!...I think that might have been enough for me to kind of give up.
It's funny however that we talk a lot about PG/VG as possible culprits, but none of us really know WHAT other ingredients go into the fabrication of these E-liquids!...:-0
__________________________________________________________________________________________________________________

Like you, I
Congrats! I hope you do find this to be a working solution. What you listed in your previous post are all classic allergic reactions. Not just to PG, that's pretty much my laundry list of symptoms of an allergic reaction to any allergen.

Again, this is not a problem for the large majority of vapers. But the potential is there and why I always suggest that anyone new to vaping stick with small sample sizes, in both high PG and high VG, to check for any exposure problems to either type of base. There is nothing worse than a huge initial $$$ outlay on a pile of liquids, only to discover you can't vape any of it. In my case the difference in reaction to a high PG liquid versus a high VG liquid was far from subtle and only took four days to reach a peak allergic reaction. PG liquid? Nausea, vomiting, difficulty breathing and intense itching on hands and forearms. VG liquid? None of that. At all.

When I started I had no idea I could have an allergic reaction to any of this. But because I stuck to samples sizes on that first order I minimized my losses to a 5 ml bottle of PG liquid and 10 pre-filled carts. And at least the carts could be rinsed out and reused.
 

callmemario

Full Member
Sep 8, 2012
29
6
Montreal
Good morning j4mmin42!
PG did have "that alcohol like taste", meaning I know it's a form of alcohol but you're right, it did have a special taste in the mouth, not a bad one for me, just headaches! :-0 I did not like those. But on the other hand VG does give me a bit of lung secretions...but not biggy, my bodey will most likely adjust. Anything that does not put one's life in danger, is alright. Allergic reaction however, are not.
I do like your idea of becoming one's own chemist! ;-) talylor made potions! ;-)
Congrats on your 300th posting! :)
_______________________________________________________________________________________________________________


High-PG liquids sometimes cause me to have a bit of asthma if I chain vape...but I can't stand the tast of pure pg anymore anyway-it just tastes chemmy to me at high concentrations. If you find a liquid that is PG and you have adverse reactions to high-PG liquids, you can do what I do and get some pharma-grade VG, order the PG eliquid you love with extra flavoring added AND a higher nic concentation, and mix the VG with it per the DIY boards' mixing ratio tutorials (or figure it out yourself-any middle-schooler can do the math here).

On another note, the is my 300th post! WOO

Fireworks.gif
 

Rickajho

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Apr 23, 2011
11,841
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Boston MA
As for allergic reactions, I've had nausea, upset stomach...but no vomiting, thank God! Poor you, that did not sound like fun!...I think that might have been enough for me to kind of give up.

I did - for several days - largely over the difficulty breathing. The acute reaction happened on day four and only after about a half dozen draws off my pv that day. They symptoms came on very quickly and were quite intense. I took several days to just calm down and research on ecf before I picked up my pv again, filled a blank cart with a VG liquid, and cautiously tested the waters again.

If you see an allergist ask them about allergic reaction to PG. Just to get more informed. My allergist said this comes up in their practice often because PG is in a lot of products applied to the face, hair and skin. My allergist wasn't surprised about my reaction to inhaling it at all. He printed out and gave me a case study report regarding allergic reaction to PG used in inhalation anesthesia. That is a potentially serious problem and anyone who has a PG allergy or suspects it needs to get that info in their medical record. Adverse reaction can be tested prior to surgery and alternate, non PG anesthesia can be used. But only if they know about it.

It's funny however that we talk a lot about PG/VG as possible culprits, but none of us really know WHAT other ingredients go into the fabrication of these E-liquids!...:-0

I believe somewhere on ecf there is a generic laundry list of possible ingredients.

Regarding the posts about alcohol and alcohol smell. To my research that typically comes from alcohol being used as a carrier for flavorings. It isn't necessarily an odor coming from a PG base liquid.
 

callmemario

Full Member
Sep 8, 2012
29
6
Montreal
Hi Rickajho,

All good points to consider but somewhat worrysome...it's like you don't know how you're going to react...Imagine PG used in facial creams, in eye drops, and lot's of other body care products...and we're inhaling this?.

YOU: "I believe somewhere on ecf there is a generic laundry list of possible ingredients"

ME: I love your expression; "generic laundry list..."again not very reassuring but nevertheless, very TRUE!
I guess we have to keep in mind the ultimate goal: Getting off analog cigarettes for good! :)
 
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Racehorse

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Jul 12, 2012
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USA midwest
Hello Versus,

I have been vaping for 3 weeks now and I love it but my body doesn't. For about two weeks, I was getting headaches after 8 or 10 drags. Tinitus in left ear some throat irritation and worst of all and persisting to this day under the eyes puffyness, like they feel congested. Took a look into my lower eye lid and found the membrane to be reddish and with a few small bubble like bumps.

I am REALLY sad and disapointed. I had cut down a lot on my smoking like 3 a day. I am waiting for some vegetable glycerine e juice only and hope it makes a difference or is it that it's the vapors itself irritating my eyes. In a ny event I am a little scared of persisting.

You could be allergic to anything, even the flavorings in the juice, the sweetner, whatever...... If your 100% vg experiment doesn't work, try vaping pure 100% VG with no nic and no flavoriings and no sweetners. Then you will know for sure.
 

callmemario

Full Member
Sep 8, 2012
29
6
Montreal
Hi Racehorse, Now THAT is VERY good advice & an excellent point!. Thank you very much! :)
Yes, you are quite right when you say that we can be allergic to anything, however it is my personal undertanding that any bodily reactions to food, medication or any kind of substance are not necessarily an allergic reaction per se IF it does not put ones life in danger. Headaches, such as the ones I was getting, would most lilely be labelled as: Side effects. My headaches never got worst of more painful. In fact the good news for today friday, is that I was almost totally free of headches due to vaping! :) BUT I will definitely consider your advice if headaches do want to show up again. Again, Thanks! :)

You could be allergic to anything, even the flavorings in the juice, the sweetner, whatever...... If your 100% vg experiment doesn't work, try vaping pure 100% VG with no nic and no flavoriings and no sweetners. Then you will know for sure.
 
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