On "Average" most mod chipsets shutoff at about 3.2v per battery. Some even though the battery recovery and hold voltage is about 3.5 to 3.6 or idle voltage, though when power is requested, especially higher amps, the battery voltage supply drops, aka voltage sag, below the 3.2v cutoff, most mods throw a low voltage signal or check batteries signal. However also, most mods on the market and especially the higher output ones like the Alien 220w, are way, in my own opinion, over speced, they can not reach these wattages constantly and still be safe, especially when you take into account on a regulated mod unlike a mechanical/unregulated mod, regulated mods pull their most amps the lower the voltage on the battery is. Nature of the beast of a regulated mod's "Boost Circuit", which what the boost circuit does, when the chip detects input voltage is lower than the voltage needed to reach set watts, the boost kicks in, pulling more amps from the batteries on top of available voltage, and converts these extra amps into raw voltage to "Boost" the voltage to the needed voltage for said set watts.
In all honesty, you have to look at what your mod, amperage wise at lowest voltage, advertises it can do, and what the batteries are actually capable of at said lower voltages. In general at a 3.2v cutoff per battery, 20amp battery max wattage is about 65watts per battery, 25amp is about 80watts per battery, 30amp is about 96watts per battery. Those are rough figures, but saying everything is ideal, you 220watt dual battery device at 6.4v lowest (3.2v X 2batteries in series),
20amp batteries and stay safe 130watts max constant wattage (65watts X 2)
25amp batteries and stay safe 160watts max constant wattage (80watts X 2)
30amp batteries and stay safe 192watts max constant wattage (96watts X 2)
and those are raw figures not taking into account the necessary voltage the chipset needs to operate which we call chipset efficiency, which most chips the average is about 90% efficiency.
(Watts Set/Lowest Voltage)/Chipset Efficiency Rating=Actual Max Raw Amps the Mod will need
To maintain 220watts consistently and be safe
220watts/6.4v=34.375amps, but take that 90% efficiency into account, 34.375amps/90%=38.1944amps <-- 8amps over what even the LG HG6's CDR is rated at, 20amp CDR battery you 18amps way over their CDR
220/7.2v=30.5556/90%=33.9506amps (3.6v per battery)
220/7.4v=29.7297/90%=33.0330amps (3.7v per battery)
220/8.0v=27.5/90%=30.5556amps (4.0v per battery) <-- a little above what an LG HB6 is rated at, but at 4.0v per battery you are not getting the best runtime, what maybe 5 to 10 minutes of vaping at that wattage range before you go over CDR once the voltage drops from 4.2v per battery fresh charge to 4.0v each battery?
Best advice I can suggest, get yourself a digital multimeter to read your batteries independently, see how each is discharging compared to the other in the mod, then plugin to the formula above what watts you are using regularly and consistently, and knowing what CDR rating of your batteries are (20, 25, 30?) you can figure out what voltage to pull and recharge them. Myself with my 150+ mods I've pulling batteries to recharge at about 1/3 to 1/4 charge indicator.