So I'd start with a little disclaimer: any voltage/wattage setting is personal preference (ie, some people like 10 watts, others 7; some people like 4 volts on a 2 ohm atty, others 4.7). With that being said, here goes:
1) A general rule of thumb for voltage to ohms, is add 2 volts to your resistance. So if you have a 2 ohm atty, start at 4 volts.
2) Watts and voltage are related by the resistance (aka ohms). They are not really independent of each other, but rather, as you adjust volts, watts will change (assuming you're resistance (ohms) is staying the same). Mathematically (and this may not be important to you, but if you like numbers), Watts = (Volts x Volts)/Resistance. So, if you are
vaping a 2 ohm atty at 4 volts, Watts = (4Vx4V)/2ohms = 8 watts. Watts is also known as power. So, lets see the watts of a 3 ohm atty at 4 volts. Watts=(4Vx4V)/3ohms=5.3 watts.
3) With the Vamo, if you are vaping in voltage mode, you will have to adjust your volts up or down depending on your atty's resistance. If you find that you like vaping at 8 watts, then whatever atty you are using, you can use the above formula to figure out what voltage to set to get that 8 watts. A lot of people however don't even think/care about watts...the voltage is simply adjusted to taste and throat hit.
4) Also with the Vamo, if you are vaping in wattage mode, it will adjust the voltage automatically to continue to give that wattage. So, if you like vaping at 8 watts, and you have a 2 ohm atty on it, the automatic voltage that the Vamo will using is 4 volts ((4Vx4V)/2ohms=8 watts). If you stick a 2.5 ohm atty on there, the Vamo will adjust its voltage to around 4.5 volts ((4.5Vx4.5V)/2.5 ohms~8 watts) so it will continue to give you that 8 watt setting.
Finally, again, the wattage/voltage setting is totally up to you. It's whatever you find you like the most. Some juices you'll see work really well with high wattage/high voltage, others may taste burnt and you will have to lower the setting.